Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers
. Lim WC, Marques Da Costa ME, Godefroy K, Jacquet E, Gragert L, Rondof W, Marchais A, Nhiri N, Dalfovo D, Viard M, Labaied N, Khan AM, Dessen P, Romanel A, Pasqualini C, Schleiermacher G, Carrington M, Zitvogel L, Scoazec JY, Geoerger B, Salmon
J. Front Immunol. 2024 Jan 22;14:1265469. doi: 10.3389/fimmu.2023.1265469. eCollection 2023. PMID: 38318504 Free PMC article.

A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.
Marques Da Costa ME, Zaidi S, Scoazec JY, Droit R, Lim WC, Marchais A, Salmon J, Cherkaoui S, Morscher RJ, Laurent A, Malinge S, Mercher T, Tabone-Eglinger S, Goddard I, Pflumio F, Calvo J, Redini F, Entz-Werlé N, Soriano A, Villanueva A, Cairo S, Chastagner P, Moro M, Owens C, Casanova M, Hladun-Alvaro R, Berlanga P, Daudigeos-Dubus E, Dessen P, Zitvogel L, Lacroix L, Pierron G, Delattre O, Schleiermacher G, Surdez D, Geoerger B.
Commun Biol. 2023 Sep 18;6(1):949. doi: 10.1038/s42003-023-05320-0. PMID: 37723198 Free PMC article.

DiPRO1 dependent transcriptional and epigenetic regulation distinctly controls the fate of muscle and mesenchymal cancer cells.
Jeremy Rich, Melanie Bennaroch, Laura Notel, Polina Patalakh, Julien Alberola, Paule Opolon, Olivia Bawa, Windy Rondof, Antonin Marchais, Philippe Dessen, Guillaume Meurice, Melanie Porlot, Karine Ser-Le Roux, Nathalie Droin, Hana Raslova, Birgit Geoerger and Iryna Pirozhkova
bioRxiv, 2023, https://www.biorxiv.org/content/10.1101/2023.01.08.523169v1.full.pdf

2021

DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability Barbara Ben Yamin, Sana Ahmed-Seghir, Junya Tomida, Emmanuelle Despras, Caroline Pouvelle, Andrey Yurchenko, Jordane Goulas, Raphael Corre, Quentin Delacour, Nathalie Droin, Philippe Dessen, Didier Goidin, Sabine S Lange, Sarita Bhetawal, Maria Teresa Mitjavila-Garcia, Giuseppe Baldacci, Sergey Nikolaev, Jean Charles Cadoret, Richard D Wood, Patricia L Kannouche
EMBO J. 2021 Sep 17;e104543. doi: 10.15252/embj.2020104543. Online ahead of print.
PMID: 34533226

The Most Common VHL Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation.
Buart S, Terry S, Diop MK, Dessen P, Couv S, Abdou A, Adam J, Thiery J, Savagner P, Chouaib S.
Cancers (Basel). 2021 Aug 2;13(15):3897. doi: 10.3390/cancers13153897.
PMID: 34359798

Dual role of EZH2 on megakaryocyte differentiation.
Mazzi S, Dessen P, Vieira M, Dufour V, Cambot M, El-Khoury M, Antony-Debre I, Arkoun B, Basso-Valentina F, Ben Abdelouahab S, Edmond V, Rameau P, Petermann R, Wittner M, Cassinat B, Plo I, Debili N, Raslova H, Vainchenker W.
Blood. 2021 Jun 11:blood.2019004638. doi: 10.1182/blood.2019004638. Online ahead of print.
PMID: 34115825

Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model.
Baloche V, Rivi re J, Tran TBT, Gelin A, Bawa O, Signolle N, Diop MBK, Dessen P, Beq S, David M, Busson P.
Sci Rep. 2021 Mar 4;11(1):5227. doi: 10.1038/s41598-021-84270-1.
PMID: 33664349

2020

Adipose Tissue Properties in Tumor-Bearing Breasts.
Miran I, Scherer D, Ostyn P, Mazouni C, Drusch F, Bernard M, Louvet E, Adam J, Mathieu MC, Haffa M, Antignac JP, Le Bizec B, Vielh P, Dessen P, Perdry H, Delaloge S, Feunteun J.
Front Oncol. 2020 Aug 21;10:1506. doi: 10.3389/fonc.2020.01506. eCollection 2020 .
PMID: 32974182 .

DNA FISH Diagnostic Assay on Cytological Samples of Thyroid Follicular Neoplasms.
Vielh P, Balogh Z, Suciu V, Richon C, Job B, Meurice G, Valent A, Lacroix L, Marty V, Motte N, Dessen P, Caillou B, Ghuzlan AA, Bidart JM, Lazar V, Hofman P, Scoazec JY, El-Naggar AK, Schlumberger M.
Cancers (Basel). 2020 Sep 6;12(9):E2529. doi: 10.3390/cancers12092529..
PMID: 32899953 .

Hypoxia increases mutational load of breast cancer cells through frameshift mutations.
Hassan Venkatesh G, Bravo P, Shaaban Moustafa Elsayed W, Amirtharaj F, Wojtas B, Abou Khouzam R, Hussein Nawafleh H, Mallya S, Satyamoorthy K, Dessen P, Rosselli F, Thiery J, Chouaib S.
Oncoimmunology. 2020 Apr 16;9(1):1750750. doi: 10.1080/2162402X.2020.1750750. eCollection 2020.
PMID: 32363122

2019

Chapiro E, Pramil E, Diop M, Roos-Weil D, Dillard C, Gabillaud C, Maloum K, Settegrana C, Baseggio L, Lesesve JF, Yon M, Jondreville L, Lesty C, Davi FB, Le Garff-Tavernier M, Droin NM, Dessen P, Algrin C, Leblond V, Gabarre J, Bouzy S, Eclache V, Gaillard B, Callet-Bauchu E, Muller M, Lefebvre C, Nadal N, Ittel A, Struski S, Collonge-Rame MA, Quilichini B, Fert-Ferrer S, Auger N, Radford-Weiss I, Wagner L, Scheinost S, Zenz T, Susin SA, Bernard OA, Nguyen-Khac F.
Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53.
Blood. 2019 Sep 16. pii: blood.2019001187. doi: 10.1182/blood.2019001187. [Epub ahead of print]
PMID: 31527074

Terry S, Abdou A, Engelsen AST, Buart S, Dessen P, Corgnac S, Collares D, Meurice G, Gausdal G, Baud V, Saintigny P, Lorens JB, Thiery JP, Mami-Chouaib F, Chouaib S.
AXL targeting overcomes human lung cancer cell resistance to NK and CTL-mediated cytotoxicity.
Cancer Immunol Res. 2019 Sep 5. pii: canimm.0903.2019. doi: 10.1158/2326-6066.CIR-18-0903. [Epub ahead of print]
PMID: 31488404

Heddar A, Dessen P, Flatters D, Misrahi M.
Novel STAG3 mutations in a Caucasian family with primary ovarian insufficiency.
Mol Genet Genomics. 2019 Jul 30. doi: 10.1007/s00438-019-01594-4. [Epub ahead of print]
PMID: 31363903

Roos-Weil D, Decaudin C, Armand M, Della-Valle V, Diop MK, Ghamlouch H, Ropars V, Herate C, Lara D, Durot E, Haddad R, Mylonas E, Damm F, Pflumio F, Stoilova B, Metzner M, Elemento O, Dessen P, Camara-Clayette V, Cosset FL, Verhoeyen E, Leblond V, Ribrag V, Cornillet-Lefebvre P, Rameau P, Azar N, Charlotte F, Morel P, Charbonnier JB, Vyas P, Mercher T, Aoufouchi S, Droin N, Guillouf C, Nguyen-Khac F, Bernard OA.
A recurrent activating missense mutation in Waldenstr m macroglobulinemia affects the DNA binding of the ETS transcription factor SPI1 and enhances proliferation.
Cancer Discov. 2019 Apr 24;. [Epub ahead of print]
PMID: 31018969

Familial predisposition to TP53/complex karyotype MDS and leukemia in DNA repair-deficient xeroderma pigmentosum.
Sarasin A, Quentin S, Droin N, Sahbatou M, Saada V, Auger N, Boursin Y, Dessen P, Raimbault A, Asnafi V, Schmutz JL, Ta eb A, Menck CFM, Rosselli F, Drieu La Rochelle L, Robert C, Sicre de Fontbrune F, S bert M, Leblanc T, Kannouche P, De Botton S, Solary E, Soulier J.
Blood. 2019 Mar 26. pii: blood-2019-01-895698. doi: 10.1182/blood-2019-01-895698. [Epub ahead of print] No abstract available.
PMID: 30914417

2018

Integrative analysis of dysregulated microRNAs and mRNAs in multiple recurrent synchronized renal tumors from patients with von Hippel-Lindau disease.
Gattolliat CH, Couv S, Meurice G, Or ar C, Droin N, Chiquet M, Ferlicot S, Verkarre V, Vasiliu V, Molini V, M jean A, Dessen P, Giraud S, Bressac-De-Paillerets B, Gardie B, Tean Teh B, Richard S, Gad S.
Int J Oncol. 2018 Jul 19. doi: 10.3892/ijo.2018.4490. [Epub ahead of print]
PMID: 30066860

Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models.
Rivera-Munoz P, Laurent AP, Siret A, Lopez CK, Ignacimouttou C, Cornejo MG, Bawa O, Rameau P, Bernard OA, Dessen P, Gilliland GD, Mercher T, Malinge S..
Blood Adv. 2018 Jul 10;2(13):1616-1627. doi: 10.1182/bloodadvances.2018016089..
PMID: 29986854

B-cell tumor development in Tet2-deficient mice..
Mouly E, Ghamlouch H, Della-Valle V, Scourzic L, Quivoron C, Roos-Weil D, Pawlikowska P, Saada V, Diop MK, Lopez CK, Fontenay M, Dessen P, Touw IP, Mercher T, Aoufouchi S, Bernard OA..
Blood Adv. 2018 Mar 27;2(6):703-714. doi: 10.1182/bloodadvances.2017014118..
PMID: 29581109

2017

Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3..
Buart S, Terry S, Noman MZ, Lanoy E, Boutros C, Fogel P, Dessen P, Meurice G, Gaston-Math Y, Vielh P, Roy S, Routier E, Marty V, Ferlicot S, Legr s L, Bouchtaoui ME, Kamsu-Kom N, Muret J, Deutsch E, Eggermont A, Soria JC, Robert C, Chouaib S..
Oncotarget. 2017 Oct 30;8(65):108786-108801. doi: 10.18632/oncotarget.22150. eCollection 2017 Dec 12..
PMID: 29312568

The microRNA-205-5p is correlated to metastatic potential of 21T series: A breast cancer progression model..
Stankevicins L, Barat A, Dessen P, Vassetzky Y, de Moura Gallo CV..
PLoS One. 2017 Mar 27;12(3):e0173756. doi: 10.1371/journal.pone.0173756. eCollection 2017..
PMID: 28346474

Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3.
Buart S, Terry S, Noman MZ, Lanoy E, Boutros C, Fogel P, Dessen P, Meurice G, Gaston-Math Y, Vielh P, Roy S, Routier E, Marty V, Ferlicot S, Legr s L, Bouchtaoui ME, Kamsu-Kom N, Muret J, Deutsch E, Eggermont A, Soria JC, Robert C, Chouaib S
Oncotarget. 2017 Dec 12;8(65):108786-108801
PMID: 29312568

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.
Thirant C, Ignacimouttou C, Lopez CK, Diop M, Le Mou l L, Thiollier C, Siret A, Dessen P, Aid Z, Rivi re J, Rameau P, Lefebvre C, Khaled M, Leverger G, Ballerini P, Petit A, Raslova H, Carmichael CL, Kile BT, Soler E, Crispino JD, Wichmann C, Pflumio F, Schwaller J, Vainchenker W, Lobry C, Droin N, Bernard OA, Malinge S, Mercher T.
Cancer Cell. 2017 Mar 13;31(3):452-465. doi: 10.1016/j.ccell.2017.02.006.
PMID: 28292442

2016

The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.
van Kempen LC, Redpath M, Elchebly M, Klein KO, Papadakis AI, Wilmott JS, Scolyer RA, Edqvist PH, Pont n F, Schadendorf D, van Rijk AF, Michiels S, Dumay A, Helbling-Leclerc A, Dessen P, Wouters J, Stass M, Greenwood CM, Ghanem GE, van den Oord J, Feunteun J, Spatz A.
Sci Transl Med. 2016 Dec 14;8(369):369ra177.
PMID: 27974665

Cytogenetic Resources and Information.
De Braekeleer E, Huret JL, Mossafa H, Dessen P.
Methods Mol Biol. 2017;1541:311-331.
PMID: 27910033

CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress.
Zhang Y, D pond M, He L, Foudi A, Kwarteng EO, Lauret E, Plo I, Desterke C, Dessen P, Fujii N, Opolon P, Herault O, Solary E, Vainchenker W, Joulin V, Louache F, Wittner M.
Sci Rep. 2016 Nov 25;6:37827. doi: 10.1038/srep37827..
PMID: 27886253.

Dux4 controls migration of mesenchymal stem cells through the Cxcr4-Sdf1 axis.
Dmitriev P, Kiseleva E, Kharchenko O, Ivashkin E, Pichugin A, Dessen P, Robert T, Copp e F, Belayew A, Carnac G, Laoudj-Chenivesse D, Lipinski M, Vasiliev A, Vassetzky YS.
Oncotarget. 2016 Aug 18. doi: 10.18632/oncotarget.11368. [Epub ahead of print]
PMID:27556182

DUX4-induced constitutive DNA damage and oxidative stress contribute to aberrant differentiation of myoblasts from FSHD patients.
Dmitriev P, Bou Saada Y, Dib C, Ansseau E, Barat A, Hamade A, Dessen P, Robert T, Lazar V, Louzada RA, Dupuy C, Zakharova V, Carnac G, Lipinski M, Vassetzky YS.
Free Radic Biol Med. 2016 Aug 9;99:244-258. doi: 10.1016/j.freeradbiomed.2016.08.007. [Epub ahead of print]
PMID: 27519269

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice.
Scourzic L, Couronn L, Pedersen MT, Della Valle V, Diop M, Mylonas E, Calvo J, Mouly E, Lopez CK, Martin N, Fontenay M, Bender A, Guibert S, Dubreuil P, Dessen P, Droin N, Pflumio F, Weber M, Gaulard P, Helin K, Mercher T, Bernard OA.
Leukemia. 2016 Jun;30(6):1388-98. doi: 10.1038/leu.2016.29. Epub 2016 Feb 15.
PMID: 26876596

Mitochondrial Proteins Containing Coiled-Coil-Helix-Coiled-Coil-Helix (CHCH) Domains in Health and Disease.
Modjtahedi N, Tokatlidis K, Dessen P, Kroemer G.
Trends Biochem Sci. 2016 Jan 15. pii: S0968-0004(15)00253-4. doi: 10.1016/j.tibs.2015.12.004. [Epub ahead of print] Review.
PMID: 26782138

2015

miR-181a modulates acute myeloid leukemia susceptibility to natural killer cells.
Nanbakhsh A, Visentin G, Olive D, Janji B, Mussard E, Dessen P, Meurice G, Zhang Y, Louache F, Bourhis JH, Chouaib S.
Oncoimmunology. 2015 Oct 16;4(12):e996475. eCollection 2015 Dec.
PMID: 26587335

New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis.
Rambow F, Job B, Petit V, Gesbert F, Delmas V, Seberg H, Meurice G, Van Otterloo E, Dessen P, Robert C, Gautheret D, Cornell RA, Sarasin A, Larue L.
Cell Rep. 2015 Oct 27;13(4):840-53. doi: 10.1016/j.celrep.2015.09.037. Epub 2015 Oct 17.
PMID: 26489459

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.
Saliba J, Saint-Martin C, Di Stefano A, Lenglet G, Marty C, Keren B, Pasquier F, Valle VD, Secardin L, Leroy G, Mahfoudhi E, Grosjean S, Droin N, Diop M, Dessen P, Charrier S, Palazzo A, Merlevede J, Meniane JC, Delaunay-Darivon C, Fuseau P, Isnard F, Casadevall N, Solary E, Debili N, Bernard OA, Raslova H, Najman A, Vainchenker W, Bellann -Chantelot C, Plo I.
Nat Genet. 2015 Oct;47(10):1131-40. doi: 10.1038/ng.3380. Epub 2015 Aug 17.
PMID 26280900

Correction of the FSHD myoblast differentiation defect by fusion with healthy myoblasts.
Dib C, Saada YB, Dmitriev P, Richon C, Dessen P, Laoudj-Chenivesse D, Carnac G, Lipinski M, Vassetzky YS.
J Cell Physiol. 2016 Jan;231(1):62-71. doi: 10.1002/jcp.25110.
PMID: 26218298

Identifying and Assessing Interesting Subgroups in a Heterogeneous Population.
Lee W, Alexeyenko A, Pernemalm M, Guegan J, Dessen P, Lazar V, Lehti J, Pawitan Y.
Biomed Res Int. 2015;2015:462549. doi: 10.1155/2015/462549. Epub 2015 Aug 3.
PMID: 26339613

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.
Saliba J, Saint-Martin C, Di Stefano A, Lenglet G, Marty C, Keren B, Pasquier F, Valle VD, Secardin L, Leroy G, Mahfoudhi E, Grosjean S, Droin N, Diop M, Dessen P, Charrier S, Palazzo A, Merlevede J, Meniane JC, Delaunay-Darivon C, Fuseau P, Isnard F, Casadevall N, Solary E, Debili N, Bernard OA, Raslova H, Najman A, Vainchenker W, Bellann -Chantelot C, Plo I.
Nat Genet. 2015 Oct;47(10):1131-40. doi: 10.1038/ng.3380. Epub 2015 Aug 17.
PMID: 26280900

Correction of the FSHD myoblast differentiation defect by fusion with healthy myoblasts.
Dib C, Saada YB, Dmitriev P, Richon C, Dessen P, Laoudj-Chenivesse D, Carnac G, Lipinski M, Vassetzky YS.
J Cell Physiol. 2016 Jan;231(1):62-71. doi: 10.1002/jcp.25110.
PMID: 26218298

2014

Hommage Alain Bernheim.
Dessen P, Larsen CJ, Valent A, Couturier J.
Bull Cancer. 2014 Oct;101(10):906-7. French. No abstract available.
PMID:25580492

A Common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults.
Bouzigon E, Nadif R, Thompson EE, Concas MP, Kuldanek S, Du G, Brossard M, Lavielle N, Sarnowski C, Vaysse A, Dessen P, van der Valk RJ, Duijts L, Henderson AJ, Jaddoe VW, de Jongste JC; GABRIEL consortium; EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium, Casula S, Biino G, Dizier MH, Pin I, Matran R, Lathrop M, Pirastu M, Demenais F, Ober C.
Clin Exp Allergy. 2014 Nov 27. doi: 10.1111/cea.12461. [Epub ahead of print]
PMID: 25431337

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis.
Couv S, Ladroue C, Laine E, Mahtouk K, Gu gan J, Gad S, Le Jeune H, Le Gentil M, Nuel G, Kim WY, Lecomte B, Pag s JC, Collin C, Lasne F, Benusiglio PR, Bressac-de Paillerets B, Feunteun J, Lazar V, Gimenez-Roqueplo AP, Mazure NM, Dessen P, Tchertanov L, Mole DR, Kaelin W, Ratcliffe P, Richard S, Gardie B.
Cancer Res. 2014 Nov 15;74(22):6554-64. doi: 10.1158/0008-5472.CAN-14-1161. Epub 2014 Nov 4.
PMID:25371412

Acquired initiating mutations in early hematopoietic cells of CLL patients.
Damm F, Mylonas E, Cosson A, Yoshida K, Della Valle V, Mouly E, Diop M, Scourzic L, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Kikushige Y, Davi F, Lambert J, Gautheret D, Merle-B ral H, Sutton L, Dessen P, Solary E, Akashi K, Vainchenker W, Mercher T, Droin N, Ogawa S, Nguyen-Khac F, Bernard OA.
Cancer Discov. 2014 Sep;4(9):1088-101. doi: 10.1158/2159-8290.CD-14-0104. Epub 2014 Jun 11.
PMID:24920063

PD-L1 is a novel direct target of HIF-1?, and its blockade under hypoxia enhanced MDSC-mediated T cell activation.
Noman MZ, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, Bronte V, Chouaib S.
J Exp Med. 2014 May 5;211(5):781-90. doi: 10.1084/jem.20131916. Epub 2014 Apr 28.
PMID:24778419

Suppressor of cytokine signaling 1 modulates invasion and metastatic potential of colorectal cancer cells.
David M, Naudin C, Letourneur M, Polrot M, Renoir JM, Lazar V, Dessen P, Roche S, Bertoglio J, Pierre J.
Mol Oncol. 2014 Mar 25. pii: S1574-7891(14)00062-3. doi: 10.1016/j.molonc.2014.03.014. [Epub ahead of print]
PMID: 24726456

Chk1 as a new therapeutic target in triple-negative breast cancer.
Albiges L, Goubar A, Scott V, Vicier C, Lef bvre C, Alsafadi S, Commo F, Saghatchian M, Lazar V, Dessen P, Delaloge S, Andr F, Quidville V. Breast. 2014 Jun;23(3):250-8. doi: 10.1016/j.breast.2014.02.004. Epub 2014 Mar 15.
PMID: 24636978

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer.
Nakouzi NA, Cotteret S, Commo F, Gaudin C, Rajpar S, Dessen P, Vielh P, Fizazi K, Chauchereau A.
Oncotarget. 2014 Feb 15;5(3):667-78.
PMID: 24525428

2013

Integrated molecular portrait of non-small cell lung cancers.
Lazar V, Suo C, Orear C, van den Oord J, Balogh Z, Guegan J, Job B, Meurice G, Ripoche H, Calza S, Hasmats J, Lundeberg J, Lacroix L, Vielh P, Dufour F, Lehti J, Napieralski R, Eggermont A, Schmitt M, Cadranel J, Besse B, Girard P, Blackhall F, Validire P, Soria JC, Dessen P, Hansson J, Pawitan Y.
BMC Med Genomics. 2013 Dec 3;6:53. doi: 10.1186/1755-8794-6-53.
PMID: 24299561

Transcriptome analysis of PPAR? target genes reveals the involvement of lysyl oxidase in human placental cytotrophoblast invasion.
Segond N, Degrelle SA, Berndt S, Clouqueur E, Rouault C, Saubamea B, Dessen P, Fong KS, Csiszar K, Badet J, Evain-Brion D, Fournier T.
PLoS One. 2013 Nov 12;8(11):e79413. doi: 10.1371/journal.pone.0079413. eCollection 2013.
PMID: 24265769

Regulation of CD4+NKG2D+ Th1 cells in patients with metastatic melanoma treated with Sorafenib: role of IL-15R? and NKG2D triggering.
Romero AI, Chaput N, Poirier-Colame V, Rusakiewicz S, Jacquelot N, Chaba K, Mortier E, Jacques Y, Caillat-Z cman S, Flament C, Caignard A, Messaoudene M, Auperin A, Vielh P, Dessen P, Porta C, Mateus C, Ayyoub M, Valmori D, Eggermont A, Robert C, Zitvogel L.
Cancer Res. 2013 Nov 6. [Epub ahead of print]
PMID:24197135

Defective Regulation of miRNAs Target Genes in Myoblasts from Facioscapulohumeral Dystrophy Patients.
Dmitriev P, Stankevicins L, Ansseau E, Petrov A, Barat A, Dessen P, Robert T, Turki A, Lazar V, Labourier E, Belayew A, Carnac G, Laoudj-Chenivesse D, Lipinski M, Vassetzky YS.
J Biol Chem. 2013 Oct 20. [Epub ahead of print]
PMID:24145033

Microarray gene expression profiling and analysis of bladder cancer supports the sub classification of the T1 tumours in T1a and T1b stages.
Descotes F, Dessen P, Bringuier PP, Decaussin M, Martin PM, Adams M, Villers A, Lechevallier E, Rebillard X, Rodriguez-Lafrasse C, Devonec M, Paparel P, Perrin P, Lazar V, Ruffion A.
BJU Int. 2013 Jul 12. doi: 10.1111/bju.12364. [Epub ahead of print]
PMID: 24053469

Microarray gene expression profiling and analysis of bladder cancer supports the sub classification of the T1 tumours in T1a and T1b stages.
Descotes F, Dessen P, Bringuier PP, Decaussin M, Martin PM, Adams M, Villers A, Lechevallier E, Rebillard X, Rodriguez-Lafrasse C, Devonec M, Paparel P, Perrin P, Lazar V, Ruffion A.
BJU Int. 2013 Jul 12. doi: 10.1111/bju.12364. [Epub ahead of print]
PMID: 24053469

Sorafenib plus dacarbazine in solid tumors: a phase I study with dynamic contrast-enhanced ultrasonography and genomic analysis of sequential tumor biopsy samples.
Lazar V, Lassau N, Meurice G, Loriot Y, Pe a C, Massard C, Robert C, Robert T, Le Berre MA, de Baere T, Dessen P, Soria JC, Armand JP.
Invest New Drugs. 2013 Aug 27. [Epub ahead of print]
PMID: 23979492

Impact of the Ku complex on HIV-1 expression and latency.
Manic G, Maurin-Marlin A, Laurent F, Vitale I, Thierry S, Delelis O, Dessen P, Vincendeau M, Leib-M sch C, Hazan U, Mouscadet JF, Bury-Mon S.
PLoS One. 2013 Jul 29;8(7):e69691. doi: 10.1371/journal.pone.0069691. Print 2013.
PMID: 23922776

A gene signature for late distant metastasis in breast cancer identifies a potential mechanism of late recurrences.
Mittempergher L, Saghatchian M, Wolf DM, Michiels S, Canisius S, Dessen P, Delaloge S, Lazar V, Benz SC, Tursz T, Bernards R, Van't Veer LJ.
Mol Oncol. 2013 Oct;7(5):987-99. doi: 10.1016/j.molonc.2013.07.006. Epub 2013 Jul 17.
PMID: 23910573

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.
Ali A, Bluteau O, Messaoudi K, Palazzo A, Boukour S, Lordier L, Lecluse Y, Rameau P, Kraus-Berthier L, Jacquet-Bescond A, Leli vre H, Depil S, Dessen P, Solary E, Raslova H, Vainchenker W, Plo I, Debili N.
Cell Death Dis. 2013 Jul 25;4:e738. doi: 10.1038/cddis.2013.260.
PMID:23887629

Developmental changes in human megakaryopoiesis..
Bluteau O, Langlois T, Rivera-Munoz P, Favale F, Rameau P, Meurice G, Dessen P, Solary E, Raslova H, Mercher T, Debili N, Vainchenker W..
J Thromb Haemost. 2013 Jun 19. doi: 10.1111/jth.12326. [Epub ahead of print].
PMID: 23782903

The combination of the antiviral agent cidofovir and anti-EGFR antibody cetuximab exerts an antiproliferative effect on HPV-positive cervical cancer cell lines' in-vitro and in-vivo xenografts.
Deberne M, Levy A, Mondini M, Dessen P, Vivet S, Supiramaniam A, Vozenin MC, Deutsch E.
Anticancer Drugs. 2013 Jul;24(6):599-608. doi: 10.1097/CAD.0b013e3283612a71.
PMID: 23698251

Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a novel set of myogenic differentiation-associated miRNAs and their target genes.
Dmitriev P, Barat A, Polesskaya A, O'Connell MJ, Robert T, Dessen P, Walsh TA, Lazar V, Turki A, Carnac G, Laoudj-Chenivesse D, Lipinski M, Vassetzky YS.
BMC Genomics. 2013 Apr 18;14:265. doi: 10.1186/1471-2164-14-265.
PMID: 23597168

Cisplatin resistance associated with PARP hyperactivation.
Michels J, Vitale I, Galluzzi L, Adam J, Olaussen KA, Kepp O, Senovilla L, Talhaoui I, Guegan J, Enot DP, Talbot M, Robin A, Girard P, Or ar C, Lissa D, Sukkurwala AQ, Garcia P, Behnam-Motlagh P, Kohno K, Wu GS, Brenner C, Dessen P, Saparbaev M, Soria JC, Castedo M, Kroemer G.
Cancer Res. 2013 Apr 1;73(7):2271-80. doi: 10.1158/0008-5472.CAN-12-3000.
PMID: 23554447

Targeting the deregulated spliceosome core machinery in cancer cells triggers mTOR blockade and autophagy.
Quidville V, Alsafadi S, Goubar A, Commo F, Scott V, Pioche-Durieu C, Girault I, Baconnais S, Le Cam E, Lazar V, Delaloge S, Saghatchian M, Pautier P, Morice P, Dessen P, Vagner S, Andr F.
Cancer Res. 2013 Apr 1;73(7):2247-58. doi: 10.1158/0008-5472.CAN-12-2501. Epub 2013 Jan 28.
PMID: 23358685

Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.
Malinge S, Thiollier C, Chlon TM, Dor LC, Diebold L, Bluteau O, Mabialah V, Vainchenker W, Dessen P, Winandy S, Mercher T, Crispino JD.
Blood. 2013 Mar 28;121(13):2440-51. doi: 10.1182/blood-2012-08-450627. Epub 2013 Jan 18.
PMID: 23335373

Atlas of genetics and cytogenetics in oncology and haematology in 2013.
Huret JL, Ahmad M, Arsaban M, Bernheim A, Cigna J, Desangles F, Guignard JC, Jacquemot-Perbal MC, Labarussias M, Leberre V, Malo A, Morel-Pair C, Mossafa H, Potier JC, Texier G, Vigui F, Yau Chun Wan-Senon S, Zasadzinski A, Dessen P.
Nucleic Acids Res. 2013 Jan;41(Database issue):D920-4. doi: 10.1093/nar/gks1082. Epub 2012 Nov 17.
PMID: 23161685

2012

From karyotype to genome wide selection (GWS) sequencing in Burkitt lymphoma.
Bernheim A, Toujani S, Dessen P.
Ann Pathol. 2012 Nov;32(5 Suppl):S46-7. doi: 10.1016/j.annpat.2012.09.193. Epub 2012 Oct 12. French.
No abstract available. PMID: 23127938

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
Thiollier C, Lopez CK, Gerby B, Ignacimouttou C, Poglio S, Duffourd Y, Gu gan J, Rivera-Munoz P, Bluteau O, Mabialah V, Diop M, Wen Q, Petit A, Bauchet AL, Reinhardt D, Bornhauser B, Gautheret D, Lecluse Y, Landman-Parker J, Radford I, Vainchenker W, Dastugue N, de Botton S, Dessen P, Bourquin JP, Crispino JD, Ballerini P, Bernard OA, Pflumio F, Mercher T.
J Exp Med. 2012 Oct 8. [Epub ahead of print] PMID: 23045605

Network enrichment analysis: extension of gene-set enrichment analysis to gene networks.
Alexeyenko A, Lee W, Pernemalm M, Guegan J, Dessen P, Lazar V, Lehti J, Pawitan Y.
BMC Bioinformatics. 2012 Sep 11;13(1):226. [Epub ahead of print] PMID: 22966941

Independent transcriptional reprogramming and apoptosis induction by cisplatin. Galluzzi L, Vitale I, Senovilla L, Eisenberg T, Carmona-Gutierrez D, Vacchelli E, Robert T, Ripoche H, J gemann N, Paccard C, Servant N, Hup P, Lazar V, Dessen P, Barillot E, Zischka H, Madeo F, Kroemer G. Cell Cycle. 2012 Sep 15;11(18):3472-80. Epub 2012 Aug 23.
PMID: 22918244

Cytogenomic studies of hydatiform moles and gestational choriocarcinoma. Poaty H, Coullin P, Leguern E, Dessen P, Valent A, Afoutou JM, Peko JF, Candelier JJ, Gomb -Mbalawa C, Picard JY, Bernheim A. Bull Cancer. 2012 Sep 1;99(9):827-843.
PMID: 22877883

Prognostic impact of vitamin b6 metabolism in lung cancer. Galluzzi L, Vitale I, Senovilla L, Olaussen KA, Pinna G, Eisenberg T, Goubar A, Martins I, Michels J, Kratassiouk G, Carmona-Gutierrez D, Scoazec M, Vacchelli E, Schlemmer F, Kepp O, Shen S, Tailler M, Niso-Santano M, Morselli E, Criollo A, Adjemian S, Jema M, Chaba K, Pailleret C, Michaud M, Pietrocola F, Tajeddine N, de La Motte Rouge T, Araujo N, Morozova N, Robert T, Ripoche H, Commo F, Besse B, Validire P, Fouret P, Robin A, Dorvault N, Girard P, Gouy S, Pautier P, J gemann N, Nickel AC, Marsili S, Paccard C, Servant N, Hup P, Behrens C, Behnam-Motlagh P, Kohno K, Cremer I, Damotte D, Alifano M, Midttun O, Ueland PM, Lazar V, Dessen P, Zischka H, Chatelut E, Castedo M, Madeo F, Barillot E, Thomale J, Wistuba II, Saut s-Fridman C, Zitvogel L, Soria JC, Harel-Bellan A, Kroemer G. Cell Rep. 2012 Aug 30;2(2):257-69. Epub 2012 Jul 26. PMID: 22854025

Array CGH and PIK3CA/AKT1 mutations to drive patients to specific targeted agents: A clinical experience in 108 patients with metastatic breast cancer. Arnedos M, Scott V, Job B, De La Cruz J, Commo F, Mathieu MC, Wolp-Diniz R, Richon C, Campone M, Bachelot T, Dalenc F, Dessen P, Lacroix L, Lazar V, Soria JC, Delaloge S, Andre F. Eur J Cancer. 2012 Oct;48(15):2293-9. doi: 10.1016/j.ejca.2012.06.014. Epub 2012 Jul 26. PMID: 22840369

Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer. Julien S, Merino-Trigo A, Lacroix L, Pocard M, Goere D, Mariani P, Landron S, Bigot L, Nemati F, Cuilliere-Dartigues P, Weiswald LB, Lantuas D, Morgand L, Pham E, Gonin P, Dangles-Marie V, Job B, Dessen P, Bruno A, Pierre A, De The H, Soliman H, Nunes M, Lardier G, Calvet L, Demers B, Prevost G, Vrignaud P, Roman-Roman S, Duchamp O, Berthet C.
Clin Cancer Res. 2012 Jul 23. [Epub ahead of print]
PMID: 22825584

A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines. Carson C, Omolo B, Chu H, Zhou Y, Sambade MJ, Peters EC, Tompkins P, Simpson DA, Thomas NE, Fan C, Sarasin A, Dessen P, Shields JM, Ibrahim JG, Kaufmann WK. Pigment Cell Melanoma Res. 2012 Jul;25(4):514-526. doi: 10.1111/j.1755-148X.2012.01010.x. Epub 2012 Jun 1. PMID: 22540896

Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.
Puget S, Philippe C, Bax DA, Job B, Varlet P, Junier MP, Andreiuolo F, Carvalho D, Reis R, Guerrini-Rousseau L, Roujeau T, Dessen P, Richon C, Lazar V, Le Teuff G, Sainte-Rose C, Geoerger B, Vassal G, Jones C, Grill J.
PLoS One. 2012;7(2):e30313. Epub 2012 Feb 28.
PMID: 22389665

Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.
Poaty H, Coullin P, Peko JF, Dessen P, Diatta AL, Valent A, Leguern E, Pr vot S, Gomb -Mbalawa C, Candelier JJ, Picard JY, Bernheim A.
PLoS One. 2012;7(1):e29426. Epub 2012 Jan 9. PMID: 22253721

2011

A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast.
Dupressoir A, Vernochet C, Harper F, Gu gan J, Dessen P, Pierron G, Heidmann T.
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1164-73. Epub 2011 Oct 27.br> PMID: 22032925

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma.
Bertolotto C, Lesueur F, Giuliano S, Strub T, de Lichy M, Bille K, Dessen P, d'Hayer B, Mohamdi H, Remenieras A, Maubec E, de la Fouchardi re A, Molini V, Vabres P, Dalle S, Poulalhon N, Martin-Denavit T, Thomas L, Andry-Benzaquen P, Dupin N, Boitier F, Rossi A, Perrot JL, Labeille B, Robert C, Escudier B, Caron O, Brugi res L, Saule S, Gardie B, Gad S, Richard S, Couturier J, Teh BT, Ghiorzo P, Pastorino L, Puig S, Badenas C, Olsson H, Ingvar C, Rouleau E, Lidereau R, Bahadoran P, Vielh P, Corda E, Blanch H, Zelenika D, Galan P; French Familial Melanoma Study Group, Aubin F, Bachollet B, Becuwe C, Berthet P, Bignon YJ, Bonadona V, Bonafe JL, Bonnet-Dupeyron MN, Cambazard F, Chevrant-Breton J, Coupier I, Dalac S, Demange L, d'Incan M, Dugast C, Faivre L, Vincent-F tita L, Gauthier-Villars M, Gilbert B, Grange F, Grob JJ, Humbert P, Janin N, Joly P, Kerob D, Lasset C, Leroux D, Levang J, Limacher JM, Livideanu C, Longy M, Lortholary A, Stoppa-Lyonnet D, Mansard S, Mansuy L, Marrou K, Mat us C, Maugard C, Meyer N, Nogues C, Souteyrand P, Venat-Bouvet L, Zattara H, Chaudru V, Lenoir GM, Lathrop M, Davidson I, Avril MF, Demenais F, Ballotti R, Bressac-de Paillerets B.
Nature. 2011 Oct 19;480(7375):94-8. doi: 10.1038/nature10539.br> PMID: 22012259

Expression of miR-487b and miR-410 encoded by 14q32.31 locus is a prognostic marker in neuroblastoma.
Gattolliat CH, Thomas L, Ciafr SA, Meurice G, Le Teuff G, Job B, Richon C, Combaret V, Dessen P, Valteau-Couanet D, May E, Busson P, Douc-Rasy S, B nard J.
Br J Cancer. 2011 Oct 4. doi: 10.1038/bjc.2011.388. [Epub ahead of print]
PMID: 21970883

A syncytin-like endogenous retrovirus envelope gene of the guinea pig specifically expressed in the placenta junctional zone and conserved in Caviomorpha.
Vernochet C, Heidmann O, Dupressoir A, Cornelis G, Dessen P, Catzeflis F, Heidmann T.
Placenta. 2011 Sep 3. [Epub ahead of print]
PMID: 21893339

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis.
Quivoron C, Couronn L, Della Valle V, Lopez CK, Plo I, Wagner-Ballon O, Do Cruzeiro M, Delhommeau F, Arnulf B, Stern MH, Godley L, Opolon P, Tilly H, Solary E, Duffourd Y, Dessen P, Merle-Beral H, Nguyen-Khac F, Fontenay M, Vainchenker W, Bastard C, Mercher T, Bernard OA.
Cancer Cell. 2011 Jun 29.
PMID:21723201

Chromosomal minimal critical regions in therapy-related leukemia appear different from those of de novo leukemia by high-resolution aCGH.
Itzhar N, Dessen P, Toujani S, Auger N, Preudhomme C, Richon C, Lazar V, Saada V, Bennaceur A, Bourhis JH, de Botton S, Bernheim A.
PLoS One. 2011 Feb 14;6(2):e16623.
PMID: 21339820

Gene expression profiling of human angiotropic primary melanoma: Selection of 15 differentially expressed genes potentially involved in extravascular migratory metastasis.
Lugassy C, Lazar V, Dessen P, van den Oord JJ, Winnepenninckx V, Spatz A, Bagot M, Bensussan A, Janin A, Eggermont AM, Barnhill RL.
Eur J Cancer. 2011 Feb 19. [Epub ahead of print]
PMID:21334873

Genomic aberrations in lung adenocarcinoma in never smokers.
Job B, Bernheim A, Beau-Faller M, Camilleri-Bro t S, Girard P, Hofman P, Mazi res J, Toujani S, Lacroix L, Laffaire J, Dessen P, Fouret P; LG Investigators.
PLoS One. 2010 Dec 6;5(12):e15145.
PMID: 21151896

Infantile convulsions with paroxysmal dyskinesia (ICCA syndrome) and copy number variation at human chromosome 16p11. Roll P, Sanlaville D, Cillario J, Labalme A, Bruneau N, Massacrier A, D lepine M, Dessen P, Lazar V, Robaglia-Schlupp A, Lesca G, Jouve E, Rudolf G, Rochette J, Lathrop GM, Szepetowski P.
PLoS One. 2010 Oct 29;5(10):e13750.
PMID: 21060786

Portrait of ependymoma recurrence in children: biomarkers of tumor progression identified by dual-color microarray-based gene expression analysis.
Peyre M, Commo F, Dantas-Barbosa C, Andreiuolo F, Puget S, Lacroix L, Drusch F, Scott V, Varlet P, Mauguen A, Dessen P, Lazar V, Vassal G, Grill J.
PLoS One. 2010 Sep 24;5(9):e12932.
PMID: 20885975

2010

Vitale I, Jema M, Senovilla L, Galluzzi L, Rello-Varona S, Metivier D, Ripoche H, Lazar V, Dessen P, Castedo M, Kroemer G.
Involvement of p38alpha in the mitotic progression of p53(-/-) tetraploid cells.
Cell Cycle. 2010 Jul 15;9(14):2823-9. PubMed : 20686359

Sarasin A, Dessen P.
DNA repair pathways and human metastatic malignant melanoma.
Curr Mol Med. 2010 Jun;10(4):413-8. Review.PMID: 20455851

Callens C, Coulon S, Naudin J, Radford-Weiss I, Boissel N, Raffoux E, Wang PH, Agarwal S, Tamouza H, Paubelle E, Asnafi V, Ribeil JA, Dessen P, Canioni D, Chandesris O, Rubio MT, Beaumont C, Benhamou M, Dombret H, Macintyre E, Monteiro RC, Moura IC, Hermine O.
Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia.
J Exp Med. 2010 Apr 12;207(4):731-50. Epub 2010 Apr 5. PubMed PMID: 20368581; PubMed Central PMCID: PMC2856037.

Galland F, Lacroix L, Saulnier P, Dessen P, Meduri G, Bernier M, Gaillard S, Guibourdenche J, Fournier T, Evain-Brion D, Bidart JM, Chanson P.
Differential gene expression profiles of invasive and non-invasive non-functioning pituitary adenomas based on microarray analysis.
Endocr Relat Cancer. 2010 Apr 21;17(2):361-71. Print 2010. PubMed PMID: 20228124.

Galluzzi L, Morselli E, Vitale I, Kepp O, Senovilla L, Criollo A, Servant N, Paccard C, Hupé P, Robert T, Ripoche H, Lazar V, Harel-Bellan A, Dessen P, Barillot E, Kroemer G.
miR-181a and miR-630 regulate cisplatin-induced cancer cell death.
Cancer Res. 2010 Mar 1;70(5):1793-803. Epub 2010 Feb 9. PubMed PMID:
20145152.

Hangen E, De Zio D, Bordi M, Zhu C, Dessen P, Caffin F, Lachkar S, Perfettini JL, Lazar V, Benard J, Fimia GM, Piacentini M, Harper F, Pierron G, Vicencio JM, Bénit P, de Andrade A, Höglinger G, Culmsee C, Rustin P, Blomgren K, Cecconi F, Kroemer G, Modjtahedi N.
A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2.
Cell Death Differ. 2010 Jan 29. [Epub ahead of print] PubMed PMID: 20111043.

Pasmant E, Ortonne N, Rittié L, Laurendeau I, Lévy P, Lazar V, Parfait B, Leroy K, Dessen P, Valeyrie-Allanore L, Perbal B, Wolkenstein P, Vidaud M, Vidaud D, Bièche I.
Differential expression of CCN1/CYR61, CCN3/NOV, CCN4/WISP1, and CCN5/WISP2 in neurofibromatosis type 1 tumorigenesis.
J Neuropathol Exp Neurol. 2010 Jan;69(1):60-9. PubMed PMID: 20010302.

2009

High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphoma.
Toujani S, Dessen P, Ithzar N, Danglot G, Richon C, Vassetzky Y, Robert T, Lazar V, Bosq J, Da Costa L, Pérot C, Ribrag V, Patte C, Wiels J, Bernheim A.
PLoS One. 2009 Sep 17;4(9):e7089.

Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines.
Olaussen KA, Commo F, Tailler M, Lacroix L, Vitale I, Raza SQ, Richon C, Dessen P, Lazar V, Soria JC, Kroemer G.
Oncogene. 2009 Sep 14. [Epub ahead of print]

MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.
Gilles L, Bluteau D, Boukour S, Chang Y, Zhang Y, Robert T, Dessen P, Debili N, Bernard OA, Vainchenker W, Raslova H.
Blood. 2009 Sep 1. [Epub ahead of print]
DRAM: a phylogenetically ancient regulator of autophagy.
Criollo A, Dessen P, Kroemer G.
Cell Cycle. 2009 Aug;8(15):2319-20. Epub 2009 Aug 1.

Astrocytes Reverted to a Neural Progenitor-Like State with Transforming Growth Factor Alpha (TGFalpha) are Sensitized to Cancerous Transformation.
Dufour C, Cadusseau J, Varlet P, Surena A, de Faria G, Dias-Morais A, Auger N, Léonard N, Daudigeos E, Dantas-Barbosa C, Grill J, Lazar V, Dessen P, Vassal G, Prevot V, Sharif A, Chneiweiss H, Junier M.
Stem Cells. 2009 Jun 18. [Epub ahead of print]

Mutation in TET2 in myeloid cancers.
Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Massé A, Kosmider O, Le Couedic JP, Robert F, Alberdi A, Lécluse Y, Plo I, Dreyfus FJ, Marzac C, Casadevall N, Lacombe C, Romana SP, Dessen P, Soulier J, Viguié F, Fontenay M, Vainchenker W, Bernard OA.
N Engl J Med. 2009 May 28;360(22):2289-301.

Two populations of double minute chromosomes harbor distinct amplicons, the MYC locus at 8q24.2 and a 0.43-Mb region at 14q24.1, in the SW613-S human carcinoma cell line.
Guillaud-Bataille M, Brison O, Danglot G, Lavialle C, Raynal B, Lazar V, Dessen P, Bernheim A.
Cytogenet Genome Res. 2009;124(1):1-11. Epub 2009 Apr 14.

Candidate Genes on Chromosome 9q33-34 Involved in the Progression of Childhood Ependymomas. Puget S, Grill J, Valent A, Bieche I, Dantas-Barbosa C, Kauffmann A, Dessen P, Lacroix L, Geoerger B, Job B, Dirven C, Varlet P, Peyre M, Dirks PB, Sainte-Rose C, Vassal G. J Clin Oncol. 2009 Mar 16. [Epub ahead of print]

Exonic expression profiling of breast cancer and benign lesions: a retrospective analysis. André F, Michiels S, Dessen P, Scott V, Suciu V, Uzan C, Lazar V, Lacroix L, Vassal G, Spielmann M, Vielh P, Delaloge S. Lancet Oncol. 2009 Feb 25. [Epub ahead of print]

Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S. Carcinogenesis. 2009 Feb 23. [Epub ahead of print]

Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array. Andre F, Job B, Dessen P, Tordai A, Michiels S, Liedtke C, Richon C, Yan K, Wang B, Vassal G, Delaloge S, Hortobagyi GN, Symmans WF, Lazar V, Pusztai L. Clin Cancer Res. 2009 Jan 15;15(2):441-51.

2008

Blons H, Pallier K, Le Corre D, Danel C, Tremblay-Gravel M, Houdayer C, Fabre-Guillevin E, Riquet M, Dessen P, Laurent-Puig P. Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma. BMC Med Genomics. 2008 Jun 12;1(1):25.

MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: a molecular portrait of stage 4S.
Bénard J, Raguénez G, Kauffmann A, Valent A, Ripoche H, Joulin V, Job B, Danglot G, Cantais S, Robert T, Terrier-Lacombe MJ, Chassevent A, Koscielny S, Fischer M, Berthold F, Lipinski M, Tursz T, Dessen P, Lazar V, Valteau-Couanet D.
Mol Oncol. 2008 Oct;2(3):261-71. Epub 2008 Jul 23.

Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas.
Kannengiesser C, Spatz A, Michiels S, Eychène A, Dessen P, Lazar V, Winnepenninckx V, Lesueur F, Druillennec S, Robert C, van den Oord JJ, Sarasin A, Bressac-de Paillerets B; EORTC Melanoma group.
Mol Oncol. 2008 Apr;1(4):425-30. Epub 2008 Jan 12.

Danoy P, Michiels S, Dessen P, Pignat C, Boulet T, Monet M, Bouchardy C, Lathrop M, Sarasin A, Benhamou S. Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers. Int J Cancer. 2008 Jul 15;123(2):457-63.

Bernheim A, Toujani S, Saulnier P, Robert T, Casiraghi O, Validire P, Temam S, Menard P, Dessen P, Fouret P. High-resolution array comparative genomic hybridization analysis of human bronchial and salivary adenoid cystic carcinoma. Lab Invest. 2008 May;88(5):464-73. Epub 2008 Mar 10.

Duret L, Cohen J, Jubin C, Dessen P, Goût JF, Mousset S, Aury JM, Jaillon O, Noël B, Arnaiz O, Bétermier M, Wincker P, Meyer E, Sperling L.  Analysis of sequence variability in the macronuclear DNA of Paramecium tetraurelia: a somatic view of the germline. Genome Res. 2008 Apr;18(4):585-96. Epub 2008 Feb 6.

Bernheim A, Toujani S, Guillaud-Bataille M, Richon C, Waxin H, Dessen P, Berger R. Intragenic breakpoints localized by array CGH in a t(2;6) familial translocation. Cytogenet Genome Res. 2007;119(3-4):185-90. Epub 2008 Feb 1.

Vitale I, Galluzzi L, Vivet S, Nanty L, Dessen P, Senovilla L, Olaussen KA, Lazar V, Prudhomme M, Golsteyn RM, Castedo M, Kroemer G. Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway. PLoS ONE. 2007 Dec 26;2(12):e1337.

S Tozlu-Kara, V Roux, C Andrieu, J Vendrell, S Vacher, V Lazar, F Spyratos, M Tubiana-Hulin, P Cohen, P Dessen , R Lidereau and I Bieche. Oligonucleotide microarray analysis of estrogen receptor a-positive postmenopausal breast carcinomas:identification of HRPAP20 and TIMELESS as outstanding candidate markers to predict the response to tamoxifen. J Mol Endocrinol. 2007 Oct;39(4):305-18.

Kauffmann A, Rosselli F, Lazar V, Winnepenninckx V, Mansuet-Lupo A, Dessen P, van den Oord JJ, Spatz A, Sarasin A. High expression of DNA repair pathways is associated with metastasis in melanoma patients. Oncogene. 2007 Sep 24; [Epub ahead of print]

Michiels S, Danoy P, Dessen P, Bera A, Boulet T, Bouchardy C, Lathrop M, Sarasin A, Benhamou S. Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. Carcinogenesis. 2007 Aug;28(8):1731-9. Epub 2007 May 10.

Bernheim A, Dessen P, Lazar V, Auger N, Fauvet D, Clausse B, Turhan A. Cryptic del(13q14.2) and physiological deletions of immunoglobulin genes detected by high-resolution array CGH in a patient with indolent chronic lymphocytic leukemia (CLL). Cancer Genet Cytogenet. 2007 Jul 1;176(1):89-91.

de La Motte Rouge T, Galluzzi L, Olaussen KA, Zermati Y, Tasdemir E, Robert T, Ripoche H, Lazar V, Dessen P, Harper F, Pierron G, Pinna G, Araujo N, Harel-Belan A, Armand JP, Wong TW, Soria JC, Kroemer G. A novel EGFR inhibitor promotes apoptosis in nonsmall cell lung cancer cells resistant to erlotinib Cancer Res. 2007 Jul 1;67(13):6253-62.

Levy P, Ripoche H, Laurendeau I, Lazar V, Ortonne N, Parfait B, Leroy K, Wechsler J, Salmon I, Wolkenstein P, Dessen P, Vidaud M, Vidaud D, Bieche I. Microarray-based identification of TNC and TNXB - two members of the Tenascin gene family - involved in tumorigenesis associated with neurofibromatosis type 1. Clin Cancer Res 2007 13: 398-407 Published Online First January 3, 2007. doi: 10.1158/1078-0432.CCR-06-0182

Raslova H, Kauffmann A, Sekkai D, Ripoche H, Larbret F, Robert T, Tronik Leroux D, Kroemer G, Debili N, Dessen P, Lazar V, Vainchenker W. Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach. Blood. 2007 Apr 15;109(8):3225-34

2006

Cayrol C, Lacroix C, Mathe C, Ecochard V, Ceribelli M, Loreau E, Lazar V, Dessen P, Mantovani R, Aguilar L, Girard JP. The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell cycle target genes. Blood. 2006 Sep 26;

Berois N, Blanc E, Ripoche H, Mergui X, Trajtenberg F, Cantais S, Barrois M, Dessen P, Kagedal B, Benard J, Osinaga E, Raguenez G. ppGalNAc-T13: a new molecular marker of bone marrow involvement in neuroblastoma. Clin Chem. 2006 Sep;52(9):1701-12. Epub 2006 Jul 27.

Le Brigand K, Russell R, Moreilhon C, Rouillard JM, Jost B, Amiot F, Magnone V, Bole-Feysot C, Rostagno P, Virolle V, Defamie V, Dessen P, Williams G, Lyons P, Rios G, Mari B, Gulari E, Kastner P, Gidrol X, Freeman TC, Barbry P. An open-access long oligonucleotide microarray resource for analysis of the human and mouse transcriptomes. Nucleic Acids Res. 2006 Jul 19;34(12):e87.

Castedo M, Coquelle A, Vivet S, Vitale I, Kauffmann A, Dessen P, Pequignot MO, Casares N, Valent A, Mouhamad S, Schmitt E, Modjtahedi N, Vainchenker W, Zitvogel L, Lazar V, Garrido C, Kroemer G. Apoptosis regulation in tetraploid cancer cells. EMBO J. 2006 Jun 7;25(11):2584-95. Epub 2006 May

Winnepenninckx V, Lazar V, Michiels S, Dessen P, Stas M, Alonso SR, Avril MF, Ortiz Romero PL, Robert T, Balacescu O, Eggermont AM, Lenoir G, Sarasin A, Tursz T, van den Oord JJ, Spatz A; Melanoma Group of the European Organization for Research and Treatment of Cancer. Gene expression profiling of primary cutaneous melanoma and clinical outcome. J Natl Cancer Inst. 2006 Apr 5;98(7):472-82.

de Reynies A, Geromin D, Cayuela JM, Petel F, Dessen P, Sigaux F, Rickman DS. Comparison of the latest commercial short and long oligonucleotide microarray technologies. BMC Genomics. 2006 Mar 15;7:51.

Aury JM, Jaillon O, Duret L, Noel B, Jubin C, M. Porcel B, Segurens B, Daubin V, Anthouard V, Aiach N, Arnaiz O, Billaut A, Beisson J, Blanc I, Bouhouche K, Camara F, Duharcourt S, Guigo R, Gogendeau D , Katinka M, Keller AM, Kissmehl R, Klotz C, Koll F, Le Mouel A, Lepere G, Malinsky S, Nowacki M, Nowak JK, Plattner H, Poulain J, Ruiz F, Serrano V, Zagulski M, Dessen P, Mireille Betermier M, Jean Weissenbach J, Scarpelli C, Schachter V, Sperling L, Meyer E, Cohen J& Wincker P. Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia. Nature, November 9, 2006.

2005

Boya P., Gonzalez-Polo R.A., Casares N., Perfettini J.-L, Dessen P., Larochette N., Metivier D., Meley D., Souquere S., Pierron G., Ohsumi Y., Codogno P. and Kroemer G. Inhibition of macroautophagy triggers apoptosis ? Mol. Cell. Biol. (2005) 1025-1040. Lacroix L, Lazar V, Michiels S, Ripoche H, Dessen P, Talbot M, Caillou B, Levillain JP, Schlumberger M, Bidart JM. Follicular thyroid tumors with the PAX8-PPARgamma1 rearrangement display characteristic genetic alterations. Am J Pathol. 2005 Jul;167(1):223-31.

2004

Tourmen Y., Ferré M., Malthiéry Y., Dessen P., Reynier P. (2004) Mitochondrial diseases preferentially involve proteins with prokaryote homologues. Comptes Rendus de l'Académie des Sciences/Biologies 327, 1095-1101. Huret JL, Senon S, Bernheim A, Dessen P An Atlas on genes and chromosomes in oncology and haematology. Cell Mol Biol (Noisy-le-grand). 2004 Nov;50(7):805-7.

Zagulski M, Nowak JK, Le Mouel A, Nowacki M, Migdalski A, Gromadka R, Noel B, Blanc I, Dessen P, Wincker P, Keller AM, Cohen J, Meyer E, Sperling L. 2004. High Coding Density on the Largest Paramecium tetraurelia Somatic Chromosome. Curr Biol 14(15):1397-1404. Beau I, Groyer-Picard MT, Desroches A, Condamine E, Leprince J, Tome JP, Dessen P, Vaudry H, Misrahi M. 2004. The basolateral sorting signals of the thyrotropin and luteinizing hormone receptors: an unusual family of signals sharing an unusual distal intracellular localization, but unrelated in their structures. Mol Endocrinol 18(3):733-746.

2003

Huret JL, Dessen P, Bernheim A. 2003. Atlas of Genetics and Cytogenetics in Oncology and Haematology, year 2003. Nucleic Acids Res 31(1):272-274.